INITIAL SURVEY OF PLA2G6 MISSENSE VARIANT CAUSING NEUROAXONAL DYSTROPHY IN PAPILLON DOGS IN NORTH AMERICA AND EUROPE

Initial survey of PLA2G6 missense variant causing neuroaxonal dystrophy in Papillon dogs in North America and Europe

Abstract Background An autosomal recessive, rapidly progressive degenerative neuropathy known as infantile neuroaxonal dystrophy (NAD) was originally reported in Papillion puppies in 1995.In 2015, a causative missense variant in the PLA2G6 gene was identified in three affected hiboost 4k smart link puppies.Archived samples from Papillons clinically

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